Publications
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2019
46. Mason, S. D.; Wang, G. A.; Yang, P.; Li, Y.; Li, F.* Probing and controlling dynamic interactions at biomolecule-nanoparticle interfaces using stochastic DNA walkers. ACS Nano, 2019, 13, 8106-8113.
45. Li, Y.; Mansour H.; Wang, T.; Poojari, S.; Li, F.* Naked-eye detection of grapevine red-blotch viral infection using a plasmonic CRISPR Cas12a assay. Analytical Chemistry, 2019, 91, 11510-11513.
44. Dong, T.; Wang, G. A.; Li, M. W.; Li, F.* Systematic investigation of quantitative paper-based DNA reader (qPDR) for distance-based quantification of nucleic acids and mercury ions. Analytical Methods, 2019, Accepted. (Invited contribution in “Analytical Methods Emerging Investigator Series”)
43. Dong, T.; Wang, G. A.; Li, F.* Shaping up field-deployable nucleic acid testing using microfluidic paper-based analytical devices. Analytical and Bioanalytical Chemistry, 2019, 411, 4401-4414. (Invited review in “Young Investigators in (Bio-)analytical Chemistry” theme issue)
42. Ding, Y.; Li, X.; Zhang, X.; Li, F.;* Hou, X.; Wu, P.* Systematic probing of the sequence selectivity of exonuclease III with a photosensitization colorimetric assay. ACS Omega, 2019, 4, 13382-13387.
41. Fan, L.;* Wang, X.; Ge, J.; Li, F.;* Zhang, C.; Lin, B.; Shuang, S.; Dong, C.* Golgi-targeted off-on fluorescent probe for real-time monitoring pH changes in vivo. Chemical Communications, 2019, 55, 6685-6688.
40. Fan, L.;* Wang, X.; Ge, J.; Li, F.;* Wang, X.; Wang, J.; Shuang, S.; Dong C.* A lysosome-targeting and polarity-specific fluorescent probe for cancer diagnosis. Chemical Communications, 2019, 55, 4703-4706.
39. LI, X.; Gao, L.; Li, F; Hong, X.; Wu, P.* Universal and label-free photosensitization colorimetric assays enabled by target-induced termini transformation of dsDNA resistant to Exo III digestion. Chemical Communications, 2019, 55, 7211-7214.
38. Wang, X. D.; Fan, L.;* Ge, J.; Li, F.; Zhang, C.; Wang, J.; Shuang, S. M.; Dong, C. A lysosome-targetable fluorescent probe for real-time imaging cysteine under oxidative stress in living cells. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2019, 221, 117175.
37. Li, F; Wang, G. A.; Dong, T. Paper-based molecular diagnostic device and uses thereof. International Patent (PCT). 2019, WO 2019/038706 A2.
2018
36. Mason, S.; Tang, Y.; Li, Y.; Xie, X.; Li, F.* Emerging bioanalytial applications of DNA walkers. Trends in Analytical Chemistry, 2018, 107, 212-221.
35. Li, Y.; Wang, G, A.; Mason, S. D.; Yang, X.; Yu, Z.; Tang, Y.; Li, F.* Simulation-guided engineering of an enzyme-powered three dimensional DNA nanomachine for discriminating single nucleotide variants. Chemical Science, 2018, 9, 6434-6439.
News Release:
Brock News-2018-07-23: Tiny robot could be game-changer in fight against tuberculosis
Newsweek-2018-07-24: Tiny robot made of gold could help with tuberculosis treatment
Business Standard-2018-07-25: Tiny robot can detect drug-resistant TB within an hour
India Today-2018-07-25: Tiny robot can detect drug-resistant TB within an hour
St. Catharines Standard-2018-07-26: Brock bot detects TB treatment resistance faster than before
Digital Trends-2018-07-26: Tuberculosis is a killer, but scientists are fighting back with nanobots
34. Li, F.;* Lin, Y.; Lau, A.; Tang, Y.; Chen, J.; Le, X. C.* Binding-induced molecular amplifier as a universal detection platform for biomolecules and biomolecular interaction. Analytical Chemistry, 2018, 90, 8651-8657.
33. Wang, G. A.; Dong, T.; Mansour H.; Matamoros, G.; Sanchez, A. L.; Li, F.* Paper-Based DNA Reader for Visualized Quantification of Soil-Transmitted Helminth Infections. ACS Sensors, 2018, 3, 205-210
News Release:
Brock News-2018-01-22: Brock researchers create groundbreaking DNA reader for disease detection
Niagara Now-2018-01-22: Brock scientists invent “groundbreaking” device
St. Catharines Standard-2018-01-26: Brock researches develop ‘beautiful’ DNA test
Lab Manager-2018-01-29: Brock researcher create groundbreaking DNA reader for disease detection
Genomeweb-2018-02-05: Paper DNA Detection Device Enables Diagnosis of Helminth Infections
360Dx-2018-02-05: Paper DNA Detection Device Enables Diagnosis of Helminth Infections
2017
32. Soleymani, L.;* Li, F.* Mechanistic Challenges and Advantages of Biosensor Miniaturization into the Nanoscale. ACS Sensors, 2017, 2, 458-467
31. Li, F.;* Li, J.; Tang, Y.; Wang, C.; Li, X.-F.; Le, X. C.* Targeted enlargement of aptamer functionalized gold nanoparticles for quantitative protein analysis. Proteomes, 2017, 5, 1 (Invited contribution in the special issue of "Approaches to Top-Down Proteomics: In Honour of Prof. Patrick H. O'Farrell")
2016
30. Yang, X.; Tang, Y.; Traynor, S. M.; Li, F.* Regulation of DNA strand displacement using allosteric DNA toehold. Journal of the American Chemical Society, 2016, 138, 14076-14082.
News release:
Brock News-2016-12-02: Computers with DNA? Brock team working to help make it happen
St. Catharines Standard-2016-12-09: Brock team researches computing power of DNA
29. Li, F.*; Tang, Y.; Traynor, S. M.; Li, X.-F.; Le, X. C.* Kinetics of proximity-induced intramolecular DNA strand displacement. Analytical Chemistry, 2016, 88, 8152-8157.
28. Yang, X.; Tang, Y.; Mason, S. D.; Chen, J.; Li, F.* Enzyme-powered three dimensional DNA nanomachine for DNA walking, payload release, and biosensing. ACS Nano, 2016, 10, 2324-2330.
News release:
Popular Science-2016-03-02: This tiny bot glows to diagnose tuberculosis
Brock News-2016-03-02: Brock team builds microscopic robot to detect diseases in blood samples
MDT News-2016-03-03: Team Builds Microscopic Robot to Catch Diseases in Blood Samples
ZDNet-2016-03-03: These microscopic robots swim in blood to diagnose disease
GyartasTrend (Hungary)-2016-03-03: Nanoméretű robotok diagnosztizálnak
MedPortal (Russia)-2016-03-03: Golden nanobots detect tuberculosis
Catalyst (Carleton University)-2016-04-02: Nanomachines to the rescue
27. Yang, X.; Tang, Y.; Alt, R. R.; Xie, X.; Li, F.* Emerging techniques for ultrasensitive protein analysis. Analyst, 2016, 141, 3473-3481. (Invited Review in "Emerging Investigator" Themed Issue)
26. Chen, J.; Deng, B.; Wu, P.; Li, F.; Li, X.-F.; Le, X. C.; Zhang, H.; Hou, X. Amplified binding-induced homogeneous assay through catalytic cycling of analytes for ultrasensitive protein detection. Chemical Communications, 2016. 52, 1816-1819.
25. Tang, Y.; Xu, Y.; Li, F.; Jamiff, L.; Steve, E. Hrudey; Li, X.-F. Non-targeted identification of peptides and disinfection byproducts in water. Journal of Environmental Sciences, 2016, 42, 259-266.
24. Tang, Y.; Li, F.; Huang, G.; Li, X.-F. Mass spectrometry analysis of peptides distributed in environment. Encyclopedia of Analytical Chemistry, 2016, Accepted.
2015
23. Tang, Y.; Wang, Z.; Yang, X.; Chen, J.; Liu, L.; Zhao, W.; Le, X. C.; Li, F.* Constructing real-time, wash-free, and reiterative sensors for cell surface proteins using binding-induced dynamic DNA assembly. Chemical Science, 2015, 6, 5729-5733.
22. Tang, Y.; Lin, Y; Yang, X.; Wang, Z.; Le, X. C.; Li, F.* Universal strategy to engineer catalytic DNA hairpin assemblies for protein analysis. Analytical Chemistry, 2015, 87, 8063-8066.
21. Li, F.;* Zhang, H.;* Wang, Z.; Newbigging, M. A.; Reid, S. M..; Li, X.-F.; Le, X. C. Aptamers facilitate amplified detection of biomolecules. Analytical Chemistry, 2015, 87, 274-292. (* These authorscontributed equally to this paper)
20. Le, X. C.; Li, F. Binding-induced formation of DNA three-way junctions from non-DNA targets. US Patent, 2015, US 2015/0219652 A1.
2014 and before
19. Paliwoda, E. R.;* Li, F.;* Reid, S. M.; Lin, Y.; Le, X. C. Sequential strand displacement beacon for detection of DNA coverage on functionalized gold nanoparticles. Analytical Chemistry, 2014, 86, 6138-6143. (* These authors contributed equally to this paper)
18. Deng, B.; Lin, Y.; Wang, C.; Li, F.; Wang, Z.; Zhang, H.; Li, X.-F.; Le, X. C. Aptamer binding assays for proteins: the thrombin example-a review. Analytica Chimica Acta, 2014, 837, 1-15
17. Li, F.; Aeran, R.; Pone, E. J.; Kang, D.-K.; Liu, L.; Le X. C.; Zhao W. Probe and control of cell-cell interactions using bioengineered tools. In “Micro and Nanoengineering of the cell surface”, edited by Weian Zhao and Jeffery M. Karp, Elsevier. 2014. In press.
16. Ali, M.M.; Li, F.; Zhang Z.; Zhang, K.; Kang, D.-K.; Ankrum, J.; Le, X. C.; Zhao, W. Rolling circle amplification: a versatile tool for chemical biology, materials science and medicine. Chemical Society Reviews, 2014, 43, 3324-3341..
15. Zhang, H.*; Li, F.*; Dever, B.; Li, X-F.; Le, X. C. DNA-mediated homogeneous binding assays for nucleic acids and proteins. Chemical Reviews, 2013, 113, 2812-2841. (* These authors contributed equally to this paper)
14. Li, F.; Zhang, H.; Wang, Z.; Li, X.; Li, X.-F.; Le, X. C. Dynamic DNA assemblies mediated by binding-induced DNA strand displacement. Journal of the American Chemical Society, 2013, 135, 2443-2446.
13. Zhang, H.; Li, F.; Dever, B.; Wang, C.; Li, X.-F.; Le, X.C. Assembling DNA through affinity binding to achieve ultrasensitive protein detection. Angewante Chemie International Edition, 2013, 52, 10698-10705.
12. Li, F.; Lin, Y.; Le, X. C. Binding-induced formation of DNA three-way junctions and its application in real-time protein detection and DNA strand displacement. Analytical Chemistry, 2013, 85, 10835-10841.
11. Li, F.; Zhang, H.; Dever, B.; Li, X.-F.; Le, X. C. Thermal stability of DNA functionalized gold nanoparticles. Bioconjugate Chemistry, 2013, 24, 1790-1797.
10. Zhang, H.; Li, F.; Li, X.-F.; Le, X. C. Yoctomole detection of proteins using solid phase binding-induced DNA assembly. Methods, 2013, 64, 322-330.
9. Liu, Y.; Wang, C.; Li, F.; Shen, S.; Le, X. C.; Li, X-F. DNase-mediated single-cycle selection of aptamers for blotted proteins on a membrane. Analytical Chemistry, 2012, 84, 7603-7606.
8. Li, F.; Zhang, H.; Lai C.; Li, X-F.; Le, X. C. A molecular translator that acts by binding-induced DNA strand displacement for a homogeneous protein assay. Angewante Chemie International Edition, 2012, 51, 9317-9320.
7. Li, F.; Dever, B.; Zhang, H.; Li, X-F.; Le, X. C. Mesoporous materials in peptidome analysis. Angewandte Chemie International Edition, 2012, 51, 3518-3519.
6. Li, F.; Li, J.; Wang, C.; Zhang, J.; Li, X.-F.; Le, X. C. Competitive protection of aptamer-functionalized gold nanoparticles by controlling DNA assembly. Analytical Chemistry, 2011, 83, 6464-6467.
5. Hamula, C.L.A.; Zhang, H.; Li, F.; Wang, Z.; Le, X. C.; Li, X.-F. Selection and analytical applications of aptamers binding microbial pathogens. Trends in Analytical Chemistry, 2011, 30, 1587-1597.
4. Li, F.; Zhao, Q.; Wang, C.; Lu, X.; Li, X.-F.; Le, X. C. Detection of E. coli O157: H7 using gold nanoparticle labeling and inductively coupled plasma-mass spectrometry. Analytical Chemistry, 2010, 82, 3399-3403.
3. Wagner, M.K.; Li, F.; Li, J.; Li, X.-F.; Le, X. C. Use of quantum dots in the development of assays for cancer biomarkers. Analytical and Bioanalytical Chemistry, 2010, 397, 3213-3224.
2. Goulko, A.A.; Li, F.; Le, X. C. Bioanalytical applications of aptamer and molecular beacon probes in fluorescence affinity assays. Trends in Analytical Chemistry, 2009, 28, 878-892.
1. Wang, Y.; Zhang, Z.; Zhang, L.; Li, F.; Chen, L.; Wan, Q. H.; Magnetically immobilized beds for capillary electrochromatography. Analytical Chemistry, 2007, 79, 5082-5086.